Policosanol research has uncovered the answer to
the best natural way to lower cholesterol.
Dr. Al Sears says, "If you
are on a statin drug, or short on energy you need
ACCEL!"
"Conventional CoQ10
works wonders for the heart, but the problem I’ve had is keeping my
patients’ blood levels high enough.
"I've
discovered a new form of CoQ10,
which I call Accel,
which has an absorption rate, which
is 8 times the regular coenzyme Q10. And that’s just the beginning…
INTRODUCTION Policosanol
Research includes well
designed clinical trials involving nearly 30,000 patients. The research
includes:
short and
long term randomized double-blind studies comparing policosanol to a
placebo as well as...
blind
comparative trials versus statin drugs, fibrates, niacin and probucol.
The
results from the policosanol research studies clearly demonstrate that policosanol
is overall the absolute best answer to high cholesterol levels whether
we are talking about a nutritional supplement, herbal product, or
pharmaceutical drug.
I'm
Gene Millen, your guide and the
owner of this website. In 1990 a heart surgeon, sawed open
my chest and stitched in bypasses to six of my favorite
heart arteries.
After spending 200 sessions in Cardiac Rehab my
wife Bernie and
I opened the Vital Life Center, a health and wellness center for the
"'50+ crowd." Our clients have
included
hundreds of people who have been at risk for a heart attack...and many
who were recovering from them.
When I first heard about
policosanol I was skeptical because it seemed too good to be true. However,
after studying the above research I not only became convinced...I got excited. This is one of the best natural products that I have ever reviewed.
Policosanol has my personal recommendation...and nothing is too good for my
heart!
Policosanol
Research shows minimum side effects. The side effects of policosanol are rare and minimal. In
policosanol research studies of 27,879 patients (17,225 patients for two years
and 10,654 patients for four years), only 86 patients
(0.31%) reported adverse effects, the most frequent of which
was weight loss. Take time to read a recent unsolicited
testimony from a very satisfied user!
Dear Gene,
"I wanted to send you an update on how the
policosanol is working for me: after a few days of
an upset stomach I started taking it after meals and
it worked fine, no problems.
But the amazing thing is, and why I’m so glad I
stuck with it....I’ve not only lost 33 pounds but
have lowered my cholesterol by 40 points...in 3 1/2
months!
I’ve been completely unable to lose weight for many
years, I tried everything....now finally something
that works!
And I feel great too – working on lowering my
cholesterol sent me to the health food store where
I’ve since stocked up on organic foods, vitamins and
supplements.... along with the policosonal I take
daily
I feel like a new woman! Thank you so much Gene!"
Betz -
Virginia Beach
POLICOSANOL RESEARCH DESCRIPTION
and MECHANISMS
Policosanol is a mixture of fatty alcohols derived from the wax of
sugarcane .(Saccharum officinarum, L.) These active substances work to
lower cholesterol levels by several mechanisms including blocking the
formation of cholesterol in the liver. The components of policosanol
include 1-octacosanol, 1-dotriacontanol, 1-triacontanol, 1- tetracosanol,
1-tetratriacontanol, 1-hexacosanol, 1-heptacosanol and 1-nonacosanol.
CHOLESTEROL MANAGEMENT
The Policosanol Research confirms that policosanol is indicated as an adjunct to dietary and lifestyle recommendations
to reduce elevated LDL-C and total cholesterol levels. Its primarily application
is in type II hypercholesterolemia including IIa subtype (characterized
by elevated total serum cholesterol and LDL-C levels) and IIb subtype
(mixed hypercholesterolemia characterized by elevated total serum cholesterol,
LDL-C and triglyceride levels). Policosanol can also be used as an
alternative
to aspirin as an anti-platelet agent.
DOSAGE
The recommended starting dose is 10-20 mg once a day with the evening
meal, since cholesterol biosynthesis is increased at night.
POLICOSANOL RESEARCH: PHARMACOKINETICS
Policosanol is rapidly absorbed based on radioactive absorption studies
in experimental animals (rats, rabbits and monkeys) and humans.1,2 Peak
levels have been achieved from 30 to 120 min after treatment in different
animal species and humans. Radioactivity is mainly distributed in the
liver while radioactivity levels in the systemic circulation are low.
This effect is an advantage for a cholesterol-lowering agent since the
liver is the main organ for synthesis and regulation of cholesterol
metabolism. Excretion studies in animals and human healthy volunteers
have demonstrated that feces is the main route for radioactivity excretion
after oral administration, urinary excretion is not relevant.
PHARMACOLOGICAL
EFFECTS
The pharmacological effects of policosanol based on the
policosanol research experimental models
can be summarized as follows:
Policosanol produces a dose-dependent and significant reduction of
serum total cholesterol and LDL-C levels.HDL-C values were also increased
in a dose-dependent manner.Triglycerides are also significantly reduced,
but the reduction is not dose-dependent.3,4,
Policosanol Research shows policosanol lowers total cholesterol and LDL-C by:
Inhibiting cholesterol synthesis at a point between the formation
of acetate and mevalonate.5,6
Exerting no direct inhibition on HMG-CoA reductase.5,6
Significantly increasing LDL receptor dependent processing as
demonstrated by increasing the incorporation of LDL into the hepatocyte
and stimulating its catabolism.5,6
Policosanol not only effectively decreases serum cholesterol levels,
but also reduces the cholesterol content in different tissues such
as liver, heart and fatty tissue.7
The cholesterol-lowering effects of policosanol are persistent and
it does not lose its effect over time.
Policosanol reduces platelet aggregation by altering prostaglandin
synthesis. Specifically, policosanol lowers serum levels of the pro-aggregatory
thromboxane A2, while increasing the anti-aggregatory prostaglandin
prostacyclin.8-10
Policosanol prevents and reverses atherosclerotic lesions and thrombosis.11-15
Policosanol prevents intimal thickening and smooth muscle cell proferation.16,17
Policosanol is an effective antioxidant in preventing LDL oxidation.18,19
CLINICAL EFFICACY
SHOWN IN POLICOSANOL RESEARCH
Policosanol is an agent to lower cholesterol with exceptional clinical
documentation demonstrating efficacy, safety and tolerability in patients
with type II hypercholesterolemia and in patients with secondary hypercholesterolemia
associated to diabetes mellitus or nephrotic syndrome.
The policosanol
research includes short and long-term, randomized, placebo-controlled
and comparative studies versus statins (lovastatin, pravastatin and
simvastatin), fibrates (bezafibrate and gemfibrozil), acipimox, and
probucol involving nearly 3,000 subjects.
In these studies, policosanol
in dosages ranging from 5 to 20 mg/day, has demonstrated significant
improvements in LDL-C, total cholesterol, HDL-C, and the ratios of total
cholesterol to HDL-C and LDL-C to HDL-C. Policosanol is shown to lower
cholesterol within the first 6-8 weeks of use.
The
recommended dosage of policosanol is 10-20 mg at the evening meal. It is
given at night because most cholesterol manufacture occurs at night. As
with other cholesterol-lowering therapies, dosage may be adjusted
periodically according to changes in blood cholesterol levels.
At a
daily dosage of 20 mg, LDL levels typically drop by 25-30% during the
first 8-12 weeks of therapy.
HDL cholesterol levels typically
increase by 15 to 25% after only two months of use.
The combined LDL
reduction and HDL increase can produce dramatic improvements in the
LDL to HDL ratio.
Figure 1. Policosanol research indicates that
the lipid-lowering effects of policosanol are dose-dependent
(% changes compared to placebo in eight-week treatment periods).22
These improvements in lipid profiles compare quite favorably to results
observed with statin drugs.
From comparative studies it can be concluded
that 10 mg of policosanol is equivalent in efficacy to 20 mg of lovastatin,
10 mg pravastatin, and 10 mg of simvastatin.But, while these drugs
have well-known side effects, policosanol is completely safe. Policosanol
has not been shown to produce any adverse drug interaction as well and
it can be used in diabetics, elderly subjects, and even in patients
with impaired liver function or severe liver damage without fear of
side effect.
In addition to its effects on cholesterol levels, policosanol
also exerts additional positive effects in the battle against atherosclerosis.
It prevents excessive platelet aggregation without effecting coagulation,
prevents smooth muscle cell proliferation into the intima of the artery,
and exerts good antioxidant effects in preventing against LDL oxidation.
Figure 2. The efficacy of 10 mg of policosanol daily is maintained
in long-term therapy (comparison vs. placebo).29
DOUBLE-BLIND STUDIES VS. CHOLESTEROL-LOWERING
DRUGS In 1997 Policosanol research compared statin drugs lovastatin
(Mevacor), simvastatin (Zocor)
and pravastatin (Pravachol)with policosanol.
Footnote. Since that time new statin drugs have come
to the market. Atorvastatin (Lipitor), rosuvastatin (Crestor) and a
combination drug called Vytorin which consists of simvastatin (Zocor)
and eztimibe. Although comparison studies have not been conducted on
these newer statin drugs they are similar in function to their
predecessors.
Vs. Lovastatin
(Mevacor)
Policosanol administered for eight weeks at 10 mg day has shown a similar
efficacy to lovastatin administered at 20 mg/day.31,32 Both drugs produced
similar decreases in LDL-C levels, while lovastatin was slightly more
effective than policosanol in reducing total cholesterol. However, the
reason is thatpolicosanol, but not lovastatin, significantly increased
HDL-C levels in these studies.
Policosanol raised HDL levels by over
17% from baseline values while lovastatin actually decreased HDL-C levels
slightly.
Another advantage for policosanol is that it has no hepatotoxic
effect. Lovastatin significantly, but moderately, increased serum
transaminases and creatine phosphokinase values while policosanol did
not. Other side effects were also noted in lovastatin-treated patients
but not in policosanol.
Vs. Pravastatin
(Pravachol)
Policosanol administered at 10 mg/day was compared with the same dosage
of pravastatin for eight weeks.33
The policosanol group demonstrated
greater percent changes of LDL-C and HDL-C than the pravastatin group.
Side effects were more frequent in the pravastatin group than in policosanol
group.
While pravastatin produced a significant increase the serum levels
of alanine and aspartate aminotransferase (ALT and AST, respectively),
policosanol exhibited no hepatotoxicity.
Figure 3. The efficacy of policosanol vs. pravastatin in type II hypercholesterolemia.33
Policosanol Research of Simvastatin
(Zocor)
Policosanol and Simvastatin were found to be equally effective at dosages
of 10 mg/day for eight weeks in patients with type-II hypercholesterolemia.34,35
In patients with type-II hypercholesterolemia and concomitant NIDDM,
policosanol, but not Simvastatin, significantly increased HDL-C levels.35
Again, more adverse experiences were and have been reported in simvastatin
treated patients than in policosanol treated patients.
Policosanol Significantly Reduced
Lp(a)
A comparative double blind clinical trial versus acipimox for eight
weeks in type II hypercholesterolemic patients has shown that policosanol
is more effective than acipimox in reducing LDL-C and total cholesterol.39
In addition, serum Lp(a) levels were significantly reduced by policosanol
treatment both in the whole study population (32.6 % reduction) as well
as in the stratum showing initial high Lp(a) levels (> 30 mg/dl) (57.4
% reduction).
Lp(a) is a plasma lipoprotein with a structure and composition
that closely resembles LDL, but with an additional molecule of an adhesive
protein called apolipoprotein (a).
Elevated plasma levels of Lp(a) are
an independent risk factor for coronary heart disease, particularly
in patients with elevated LDL cholesterol levels.
A high level
of Lp(a) has been shown to carry a ten times greater risk for heart
disease than an elevated LDL cholesterol level. That is because LDL
on its own lacks the adhesive apolipoprotein (a). As a result, LDL does
not easily stick to the walls of the artery. Levels of Lp(a) below 20
mg/dl are associated with a low risk for heart disease; levels between
20 and 40 mg/dl a moderate risk; and levels above 40 mg/dl an extremely
high risk for heart disease.
DOUBLE-BLIND TRIALS IN SPECIAL POPULATIONS
Policosanol Research in Diabetics
Policosanol administered to non-insulin dependent diabetes mellitus
(NIDDM) patients with type-II hypercholesterolemia significantly lowered
LDL-C, serum total cholesterol and atherogenic ratios, while increasing
HDL-C levels. In addition, policosanol does not impair glycemic control
in diabetic patients as assessed through the evaluation of its effects
on blood glucose and glycosylated hemoglobin (HgbA1c) values.41,42
Table 2. Effect of policosanol on serum lipid profile
of patients with NIDDM.41
Treatment
Baseline
12 weeks
Percent change
Total cholesterol (mmol/L)
Policosanol
Placebo
7.51
7.94
5.35
8.01
-28.9 +0.4
LDL-C (mmol/L)
Policosanol
Placebo
5.27
5.32
3.05
5.56
-44.4
+3.4
HDL-C (mmol/L)
Policosanol
Placebo
1.47
1.51
1.58
1.52
+23.5
+0.7
Triglycerides (mmol/L)
Policosanol
Placebo
2.06
2.45
1.96
2.11
-2.4
+6.5
Total cholesterol to HDL-C
Policosanol
Placebo
5.88
5.72
3.52
6.03
-38.3
+3.8
LDL-C to HDL-C
Policosanol
Placebo
4.25
3.99
2.01
4.16
-51.6 +2.9
Policosanol Research in Hypertensive patients (high
blood pressure)
Policosanol significantly reduced LDL-C (-19.1%), total cholesterol
(-13%) and the ratios of cholesterol to HDL-C (-20%) and LDL-C to HDL-C
(-24.2%) in hypertensive patients with hypercholesterolemia, while significantly
increasing HDL-C levels (+17.1%).43
After 12 months of therapy
policosanol
significantly lowered systolic pressure (-10 mm Hg), while in the placebo
group the values remained unchanged.
Many of the patients were on
beta-blockers
and diuretics, two classes of drugs known to adversely impact blood
lipid levels.
Policosanol
Research in Elderly Patients
Policosanol administered for short or long-term in patients over the
age of 60 years with hypercholesterolemia has been effective, safe and
well tolerated.44,45
In this population policosanol has a similar efficacy
profile to that observed in patients below 60 years old. Table 3 summarizes
the main results obtained at months 6 and 12 in a long-term study performed
in elderly patients.
Of particular importance in this population is
the fact that no drug-related adverse experiences have been shown. Elderly
patients are at risk for such problems due to impaired renal and hepatic
clearance as well as a high coexistence of concomitant diseases and
of medications consumption are present.
Table 3. Effect of policosanol on the serum lipid
profile in elderly patients with hypercholesterolemia
Treatment
Baseline
6 months
12 months
Percent change
Total cholesterol (mmol/L)
Policosanol
Placebo
7.68
7.33
6.67
7.46
6.43
7.57
-16.4 +0.03
LDL-C (mmol/L)
Policosanol
Placebo
5.40
4.99
4.34
5.22
4.10
5.24
-24.1 +4.8
HDL-C (mmol/L)
Policosanol
Placebo
1.28
1.28
1.28
1.25
1.36
1.25
+5.9
-2.4
Patients with Type II Hypercholesterolemia and Disturbances of Hepatic
Function
The efficacy pattern of policosanol in patients with type II hypercholesterolemia
and concomitant disturbances of hepatic function is similar to that
shown in hypercholesterolemic patients without impairment of liver function.46
Policosanol reduced total cholesterol (-13.6%), LDL-C (-19.1%), LDL-C
to HDL-C ratio (-25.5%) and raised HDL-C (+11.5%). In addition, policosanol
was shown to reduce levels of alanine aminotransferase (ALT) and gamma-glutamyltranspeptidase
(GGT) toward normal values.
Policosanol in the Nephrotic Syndrome
Policosanol reduced effectively total cholesterol, LDL-C and triglycerides
values while increasing HDL-C levels in patients with the nephrotic
syndrome without adversely affecting renal function.47
POLICOSANOL RESEARCH: ANTI-PLATELET EFFECTS
Policosanol reduces platelet aggregation by altering prostaglandin synthesis.
Specifically, policosanol lowers serum levels of the pro-aggregatory
thromboxane A2, while increasing the anti-aggregatory prostaglandin
prostacyclin.
Clinical trials in humans have shown that
policosanol
significantly inhibits platelet aggregation without affecting coagulation
parameters.9-11Policosanol's effects on platelet aggregation compare
quite favorably to low-dose aspirin.48
Table 5. Effects of policosanol (10 mg/day) or placebo
on platelet aggregation in 30 healthy volunteers
Baseline
After treatment
Difference
Arachidonic acid 0.5 M
Policosanol
Placebo
68.5
70.0
43.3
72.5
-25.2
+2.6
Epinephrine 1.25 x 10-5 M
Policosanol
Placebo
63.8
59.1
46.0
62.8
-17.8
+3.8
Collagen 0.5 mcg/ml
Policosanol
Placebo
67.7
64.0
51.8
67.5
-16.0
+3.6
ADP 2 x 10-6 M
Policosanol
Placebo
56.7
54.7
50.9
57.9
-5.8
+3.2
POLICOSANOL RESEARCH SHOWS ANGINA IMPROVEMENT Policosanol was shown to improve the clinical evolution, and exercise-ECG
testing responses of coronary heart disease (CHD) patients with myocardial
ischemia, documented by exercise myocardial perfusion scintigraphy.49
In the double-blind study, 15 patients were treated with 5 mg of policosanol
twice daily; another 15 patients were administered the same dose plus
125 mg aspirin; and the other 15 patients received placebo plus equal
aspirin dose. They were followed for 20 months, previous baseline observations,
with treadmill exercise-ECG, besides serum lipid test.
Beneficial changes
on proportions among the 2 policosanol groups and the placebo group, showed
an increment on functional capacity class, a decrement on rest and exercise
angina, and a significant decrease in cardiac events, and in ischemic
ST segment response, especially in the policosanol plus aspirin group.
POLICOSANOL SIDE EFFECTS, SAFETY AND TOXICOLOGY Policosanol exhibits an exemplary safety profile. In all controlled studies,
policosanol has exerted no negative effect of any clinical or laboratory
parameter. Side effects were comparable to a placebo.
The withdrawal
rate for policosanol in short and long-term clinical studies was comparable
or even lesser than that of placebo; only 0.2 % policosanol-patients withdrew
before conclusion of the study as a result of an adverse experience, compared
with 0.6 % of placebo patients. Comparative studies have shown a dropout
rate due to side effects of 0.9% in policosanol-treated patients compared
with a 4.4% rate for those treated with other lipid-lowering drugs (e.g.,
statins, fibrates, probucol, and acipimox).
In a large post marketing
surveillance study, the tolerability of policosanol was assessed in 27,879
patients (17,225 patients for two years and 10,654 patients for four years).
All of the patients were treated for at least one month. During the study,
86 patients (0.31%) reported adverse effects, the most frequent of which
was weight loss.
A single dose (1,000 mg/day) as much as 50 times
the maximum recommended dose (20 mg/day) administered to healthy volunteers
produced no adverse reaction, hence no over dosage symptoms have been
detected.
Animal
policosanol research studies demonstrate the policosanol is virtually non-toxic
as the oral LD50 in rats, mice, rabbits and dogs was > 5 000 mg/kg. Body
weight gain, behavioral assays, as well as biochemical and hematological
determinations in surviving animals at the end of the test (14 days) did
not reveal differences between treated and control groups. Moreover, weight
organ analysis and histopathological study did not reveal differences
between groups.51,52
The effects of successive dosage increases of policosanol
administered orally to Macaca arctoides monkeys demonstrated that even
the highest dose administered (500 mg/kg) Policosanol was tolerated. Similar
results have been shown oral subchronic and chronic toxicity models in
rats, dogs, and monkeys.53-55 Policosanol did not produce any adverse
effects on fertility and reproduction in animal studies, nor has it exerted
any mutagenic or carcinogenic effects.56-60
Specifically, policosanol
administered orally up to 500 and 1000 mg/kg during the organogenesis
period did not produce embryotoxic nor teratogenic effects in rats or
rabbits and a multigenerational study did not shown any toxicity.
CONTRAINDICATIONS
TO POLICOSANOL Pregnancy
Although policosanol neither induced teratogenic effects in rats or rabbits
nor affected rat fertility and reproduction, the treatment is not allowed
to use in pregnant women. The reason for this restriction is that cholesterol
and associated metabolic products are required for an adequate fetal development.
Since hypercholesterolemia and atherosclerosis are chronic diseases, the
suspension of lipid-lowering therapy for 9 months cannot be considered
as an additional coronary risk factor.
Lactation
It is not known whether the product or some active metabolite is excreted
via the human milk during nursing, therefore therapy should be discontinued
during lactation.
Pediatric use
Efficacy and safety of policosanol in children has not been well established.
Thus, treatment of children with policosanol is not recommended at the
present.
POLICOSANOL DRUG INTERACTIONS Aspirin The policosanol research has demonstrated synergism with the anti-platelet properties
of aspirin in experimental animal models and healthy human volunteers
as well as in different experimental animal models of ischemia and thrombosis.
Pretreatment with policosanol inhibited aspirin-induced gastric ulcer
in experimental animals.
Anticoagulants
Single or repeated doses of policosanol administered orally did not significantly
affect fibrinolytic activity or bleeding time in rats. In these studies
interaction between policosanol and heparin or warfarin have been ruled
out.61
Antipyrine and theophylline
Antipyrine is a model drug used to investigate interaction with drugs
metabolized by liver microsomal enzymes (the P-450 system). Policosanol
administered orally to Beagle dogs for 3 to 4 weeks did not affect antipyrine
or theophylline pharmacokinetics, suggesting that it does not interact
with drugs metabolizing processes involving the P-450 microsomal system.
Other concomitant therapies
Although no specific policosanol research has been developed to evaluate its
possible pharmacological interactions, in short and long-term clinical
studies policosanol has been simultaneously employed each of the
following drugs without evidence of clinically relevant adverse
interactions.
calcium antagonists,
inhibitors of angiotensin-converting enzyme,
beta-blockers,
meprobamate,
diuretics,
nitroderivative vasodilators,
non-steroidal anti-inflammatory
drugs,
anxiolytics,
anti-depressant,
neuroleptics, oral hypoglycemic agents,
digoxin,
warfarin,
thyroid hormones,
anti-ulcer drugs,
between
others
Policosanol Dosage Although the tolerability profile remains
excellent increasing the dose to 40
mg/day does not offer significant additional cholesterol-lowering benefits
over the 20 mg/day dose.
SUMMARY OF POLICOSANOL RESEARCH
Policosanol is a mixture of fatty alcohols derived from the wax of sugar
cane. These active substances work to lower cholesterol levels by several
mechanisms. It inhibits cholesterol manufacturer but does so prior to
HMG-CoA reductase. In addition policosanol also exerts exceptional effects
on LDL-cholesterol metabolism.
Specifically,
policosanol increases LDL
receptor processing. It exerts this effect by increasing the binding of
LDL to its receptor, improving the transport of LDL into the liver cell,
and significantly enhancing the breakdown of LDL cholesterol.
In addition
to lowering LDL,policosanol has also been shown to increase HDL, protect
against free radical damage to LDL-cholesterol, and inhibit excessive
platelet aggregation.
All together, policosanol exerts many pharmacological
actions of benefit in the prevention and treatment of atherosclerosis
or hardening of the arteries. The clinical documentation for policosanol
is exceptional.
Well-designed clinical trials have included short and
long-term, randomized, double-blind studies comparing policosanol to a
placebo as well as double-blind comparative trials versus statin drugs,
fibrates, acipimox, and probucol.
Policosanol produces cholesterol-lowering
effects within the first 6-8 weeks of use. At a daily dosage of 10-20 mg
of policosanol at night, LDL cholesterol levels typically drop by 20 to
25% within the first six months of therapy.
At a dosage of 20 mg, LDL
levels typically drop by 25-30%. HDL cholesterol levels typically increase
by 15 to 25% after only two months of use.
The combined LDL reduction
and HDL increase can produce dramatic improvements in the LDL to HDL ratio.
Policosanol is completely safe. Policosanol has not been shown
to produce any drug interaction when used a wide range of concomitant
therapiesand has been used effectively in the following
populations:
diabetics,
elderly subjects,
patients with
impaired liver function or severe liver damage without fear of side effects.
Summary
The benefits of
policosanol are well documented by
studies of nearly 30,000 persons. It comes with recommendations from recognized
authorities such as Dr. Michael Murray. Unlike statin drugs such
as Lipitor, Crestor and Zocor, side effects are rare and minimal.
My name is
Gene Millen, your guide and the
owner of this website. In 1990 a heart surgeon, sawed open
my chest and stitched in bypasses to six of my favorite
heart arteries.
In 1990 a heart surgeon, sawed
open my chest and stitched in bypasses to six of my favorite
heart arteries.
This got my attention... and
for the last 21 years I have been researching ways to keep my heart ticking for a long, long time.
So far it's working great! I recently celebrated my 80th
birthday and am employed as a Fitness Director, in addition
to managing this website and another part time business. (No
brag, just fact.)
After spending 200 sessions in Cardiac Rehab my
wife Bernie and
I opened the Vital Life Center, a health and wellness center for the
"'50+ crowd." Our clients have
included
hundreds of people who have been at risk for a heart attack...and many
who were recovering from them.
When I first heard about
policosanol I was skeptical because it seemed too good to be true. However,
after studying the above research I not only became convinced...I got excited. This is one of the best natural products that I have ever reviewed.
Policosanol has my personal recommendation...and nothing is too good for my
heart!
A word of caution
. Nutritional supplements aren't regulated by the FDA and studies show that many products do not
contain the ingredients shown on the label.
Consumer Lab tested 7 policosanol supplements and found that four contained only
23% to 78% of the ingredients listed on the bottle. "Let the buyer
beware."
It's also wise to avoid brands made with
bees wax or plant waxes as many are not as effective as the sugar cane formulas. The
University of Kansas Hospital "Natural Pharmacist" website
reports, "There is reason for concern that
policosanol products made
with bees wax may not be effective."
I like the fact that they are
made with sugar cane and use the exact same
formula used in the clinical trials. They also provide a "no quibble money back
guarantee" if for some reason policosanol doesn't work for you...which is
highly unlikely.
Most of the "cheap" brands
don't give a breakdown of the ingredients...and you will want to read the fine print
in their "guarantee" very carefully.
Yours for a vital and healthy heart for
life!
Here's what one of our
satisfied customers said:
"I was afraid it might
just be 'snake oil' but I went ahead and ordered it
because I hated the thought of being on Lipitor."
"My cholesterol was 397 and my doctor wanted to
put me on Lipitor but I was afraid of the side effects.
Gene gave me
the research information on policosanol for my
doctor to review and although he was somewhat
skeptical he gave me the go ahead to give it a
try.
When I got
my first follow up test after 8 later total
cholesterol had dropped to 240. But the best
news is that my HDL cholesterol was up which
improved my ratio from 7 to 4.3 which is very good.
I am elated
and my doctor was pleased and I think a little bit
surprised. He said "Keep on doing what you're
doing." — Edith Mc Gregor
You may still be skeptical
about trying this all safe, all natural product. I know I was when I first learned about policosanol and before I began to use it to change my life.
Following are my personal results:
"After 60 days on policosanol I had my cholesterol checked and my total cholesterol dropped from 255 to 226 but the best news is that the HDLs went up 43% and LDLs dropped 14% for an improvement in the important Cholesterol to HDL ratio of a whopping 38%. Triglycerides also dropped 100 points, from 167 to 67,a 60% improvement."
I really like the fact that the
20 mg Extra Strength Policosanol
replicates the exact same formula that was used in
the clinical trials.
You can find cheaper products but none with the
quality of Vital Life Nutritionals. I guarantee it!
Gene Millen
There are some
very good
reasons why you should choose
Vital Life Nutritionals.Here are just
a few of them:
·
Vital Life Nutritionalsare
manufactured by Vitamer Labs, a pharmaceutically
registered facility that has been a leader in the
manufacturing of natural supplements for decades.
During World War II they provided pharmaceuticals to
the GIs.
· These all-natural
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POLICOSANOL RESEARCH REFERENCES
1. Dalmer Laboratory. (1990): Policosanol: Experimental
Pharmacokinetics. Data on file.
2. Menindez R., Sotolongo V., Fraga V., et al. (1996): Niveles plasmaticus
y cxcrecion de la radiactividad total en voluntariois sanos tras la administracion
ora de octacosanol-3H. Rev. CENIC Cicn. Biol. 27:32-35.
3. Arruzazabala M. L., Carbajal D., Mas R., et al. (1994): Cholesterol-lowering
effects of policosanol in rabbits. Biol. Res. 27:205-209.
4. Menindez R., Arruzazabala M.L., Mas R., et al. (1997): Cholesterol-lowering
effect of policosanol on rabbits with hypercholesterolemia induced by
a wheat starch-casein diet. Br. J. Nutr. 77:323-932.
5. Menindez R., Fernandez L, Del Rio A., et al. (1994): Policosanol inhibits
cholesterol biosynthesis and enhances LDL processing in cultured human
fibroblasts. Biol. Res. 27:199-203.
6. Menindez R., Amor A.M. Gonzilez R.M. Fraga V. and Mds R. (1996): Effect
of policosanol on the hepatic cholesterol biosynthesis of normocholesterolcmic
rats. Biol. Res. 29:253-257.
7. Cruz Bustillo D., Mederos C.M. Mas R., et al. (1991): Efecto hipocolesterol
mico del Ateromixol (PPG) en el cerdo en ceba. Rev. CENIC Cien. Biol.
22:62-63.
8. Arruzazabala M. L., Valdes S., Mas R., et al. (1995): Effect of policosanol
succesive dose increase in platelet aggregation healthy volunteers. Pharmacol.
Res. 34:181-185.
9. Valdes S., Arruzazabala M.L., Carbajal D., et al. (1996): Effect of
policosanol on platelet aggregation in healthy volunteers. Intern. J.
Clin. Pharmacol. Res. 16:67-72.
10. Carbajal D, Arruzazabala M. L., Mas R., et al. (1998): Effect of policosanol
on platelet aggregation and serum levels of arachidonic acid metabolites
in healthy volunteers. Prostaglandins Leuko. Essent. Fatty Acids 58(1):61-4.
11. Noa M., Herrera M., Magrancr J. and Mas R. (1994): Effect of policosanol
on isoprenaline-induccd myocardial necrosis in rats. J. Pharm. Pharmacol.
46:282-285.
12. Carbajal D, Arruzazabala M. L., Mas R., et al. (1994). Effects of
policosanol on experimental thrombosis models. Prostaglandins Leuko. Essent.
Fatty Acids 50:249-251.
13. Arruzazabala M.L., Carbajal D., Molina V., et al. (1993): Effect of
policosanol on cerebral ischcmia in mongolian gerbils: Role of prostacyclin
and thromboxane Az. Prostaglandins Leuko. Essent. Fatty Acids 49:695-697.
14. Noa M., Mas R., and Magraner J. (1994): Effect of policosanol on lipofundin-induced
lesions in rats. J. Pharm. Pharmacol. 47:289-291.
15. Noa M., Mas R. and Mesa A. del R. (1997): Effect of policosanol in
circulating endothelial cell in experimental models in Sprague-Dawley
rats and in rabbits. Br. J. Nutr. 49:999-1002.
16. Noa M, Mas R, Mesa R. (1998): Effect of policosanol on intimal thickening
in rabbit cuffed carotid artery. Int. J. Cardiol. 67(2):125-32,
17. Batista J., Stusser I. L., Penichet M. and Uguet E. (1995): Doppler-ultrasound
pilot studyof thecffects of long-term policosanol therapy on carotid-vertebral
atherosclerosis. Curr. Ther. Res. 56:906-914.
18. Fraga V., Menindez R., Anior A.M., et al. (1997): Effect of policosanol
on in vivo and in vitro rat liver microsomal lipid pcroxidation. Arch.
Medical Res. 28:355-360.
19. Mas R., Menindez R., Fraga V., etal. (1997): Modification of rat lipoprotein
peroxidation by oral administration of policosanol. Abstract from the
4th International Conference on Preventive Cardiology, June 29-July3.
Can. J. Cardiol. 13:Suppl. B. 310B.
20. Hernendez F., Illnait J., Mas R., et al. (1992): Effects of policosanol
on serum lipids and lipoproteins in healthy volunteers. Curr. Ther. Res.
51:568-575.
21. Pons P., Mas R., Illnait J., et al. (1992): Efficacy and safety of
policosanol in patients with primary hypercholesterolemia. Curr. Ther.
Res. S2:507-513.
22. Pons P., Rodriguez M., Robaina C., et al. (1994): Effects of succesive
dose increases of policosanol on lipid profile of patients with type-II
hypercholesterolemia and tolerability to treatment. J. Clin. Pharmacol.
Res. 14:27-33.
23. Soltero I., Fuenmayor I., Colmenares J. (1993): Ensayo doble ciego
para la evalaucion del policosanol en el tratamiento de la hiperlipoproteinemia
tipo II. Arch. Venezol. Farmacol. Terap. 12:65-70.
24. Aneiros E. Calderon B., Mas R., et al. (1993): Effects of successive
dose increases of policosanol on the lipid profile and tolerability of
treatment. Curr. Ther. Res. 54:304-312.
25. Aneiros E. Calderon B., Mas R., et al. (1995), Effect of policosanol
in cholesterol-lowering levels in patients with type-II hypercholesterolemia.
Curr. Ther. Res. 56:176-182.
26. Pons P., Rodriguez M., Mas R., et al. (1994): One-year efficacy and
safety of policosanol in patients with type-II hypercholesterolemia. Curr.
Ther. Res. 55:1084-1092.
27. Castano G., Mas R., Nodarse M., et al. (1995): One-year study of the
efficacy and safety of policosanol (5 mg twice daily) in the treatment
of type II hypercholesterolemia. Curr. Ther. Res., 56:296-304.
28. Canetti M., Morera M., Illnait J., et al. (1995): One year study on
the effect of policosanol (5 mg-twice-a-day) on lipid profile in patients
with type II hypercholesterolemia. Adv. Ther. 12:245-254.
29. Canetti M., Morera M., Illnait J., et al. (1995): A two year study
on the efficacy and tolerability of policosanol in patients with type
II hypercholesterolemia. Intern. J. Clin. Pharmacol. Res. 15:159-165.
30. Canetti M., Morera M., Mas R., et al. (1997): Effects of policosanol
on primary hypercholesterolemia: A 3-year open follow-up. Curr. Ther Res.
58:868-75.
31. Castano G., Nodarse M., Mas R., et al. (1996): Comparaciones de los
efectos del policosanol y la lovastatina en pacicntes con hipercolesterolemia
primiaria tipo II. Rev. CENIC Cicn. Biol. 27:57-63.
32. Dalmer Laboratory. Policosanol vs lovastatin: Comparative study on
efficacy, safety and tolerability in the treatment of type-II hypercholesterolemia.
Data on file.
33. Benitez M., Romero C., Mas R., et al. (1997): A comparative study
of policosanol vs pravastatin in patients with type-II hypercholesterolemia.
Curr. Ther. Res. 58:859-67.
34. Ortensi G., Gladstein J., Vail H. and Tesone P.A. (1997): A comparativc
study of policosanol vs. simvastatin in elderly patients with hypercholesterolemia.
Curr. Ther. Res. 58:390-401.
35. Illnait J., Castano G., Mas R. and Fernandez J.C. (1997): A comparative
study on the efficacy and tolerability of policosanol and simvastatin
for treating type II hypercholesterolemia. Abstract front the 4th International
Confereiicc on Preventive Cardiology. June 29-July 3. Can. J. Cardiol.
13:Suppl. B, 342B.
36. Canetti M., Morera M., Illnait J., et al. (1996): Estudio coniparativo
de los efectos del policosanol y cl gemfibrozil cn pacientes con hipercolesterolemia
primaria tipo II. Rev. CENIC Cicn. Biol. 27:64-70.
37. Soltero I., Fuenmayor I., Colmenares J. (1993): Estudio comparativo
doble ciego de la eficacia y tolcrancia del policosanot vs. bezafibrato
en pacientes con hiperlipidemia tipo II. Arch. Venezol. de Farmacol. Terap.
12:71-76.
38. Pons P., Fernandez L., Mas R. et al. (1996): Estudio coniparativo
de los efectos del policosanol y el bezafibrato en pacientes con hipercolesterolemia
primaria tipo II. Rev. CENIC Cien. Biol. 27:71-77
39. Alcocer L, Campos A., Mas R. and Fernandez L. (1997): A comparative
study of policosanol vs acipimox in patients with type II hypercholesterolemia.
Data on file.
40. Pons P., Illnait J., Mas R., et al. (1997): A comparativc study of
policosanol versus probucol in patients with hypercholesterolemia. Curr.
Ther. Res. 58:26-35.
41. Torres O., Agramonte A. J., Illnait J., et al. (1995): Treatment of
hypercholesterolemia in NIDDM with policosanol. Diabetes Care 18:393-397.
42. Crespo N., Alvarez R., Mas R., et al. (1997): Effect of policosanol
on patients with non-insulin-dependent diabetes mellitus and hypercholesterolemia:
A pilot study. Curr. Ther. Res. 58:44-51.
43. Castano G., Tula L., Canetti M., et al. (1996): Effects of policosanol
in hypertensive patients with type II hypercholesterolemia. Curr. Ther.
Res. 57:691-699.
44. Pons P., Jimenez A., Rodriguez M., et al. (1993): Effects of policosanol
in elderly hypercholesterolemic patients. Curr. Ther. Res. 53:265-269.
45. Castano G., Canetti M., Morera M., et al. (1995): Efficacy and tolerability
of policosanol in elderly patients with type-II hypercholesterolemia:
A 12 months study. Curr. Ther. Res. 56:819-828.
46. Zordoya R., Tula L., Castano G., Mas R., et al. (1996): Effects of
policosanol on hypercholesterolemic patients with disturbances on serum
biochemical indicators of hepatic function. Curr. Ther. Res. 57:568-577.
47. Davalos J.M., Mederos H., Rodriguez J., et al. (1996): Effect of policosanol
in hypercholesterolemia due to nephrotic syndrome. X Latinciamerican Congress
of Nephrology and Hypertension, 14 September, Santiago de Chile, Chile.
48. Arruzazabala M. L., Carbajal D., Mas R. and Valdes S. (1997): Comparative
study of policosanol, aspirin and the combination therapy policosanol-aspirin
on platelet aggregation in healthy volunteers. Pharmacol Res 36(4):293-7.
49. Stusser R., Batista J., Padron R. et al. (1998): Long-term therapy
with policosanol improves treadmill exercise-ECG testing performance of
coronary heart disease patients. Int J Clin Pharmacol Ther 36(9):469-73.
50. Fernandez L., Mas R., Illnait J., Fernandez J.C. (1998): Policosanol:
Results of a postmarketing survellance study of 27,879 patients. Curr.
Ther. Res. 59:7717-22.
51. Aleman C.L., Mas R., Rodeiro L., et al. (1991): Toxicologia aguda
del Ateromixol (PPG) en roedores. Rev. CENIC Cien. Biol. 22:102-105.
52. Aleman C.L., Mas R., Rodeiro I., et al. (1992): Acute, subchronic
and chronic toxicology of policosanol in rats. Toxicol. Letters. Suppl.2:248.
53. Rodriguez C., Mesa R., Mas R., et al. (1994): Study of policosanol
oral chronic toxicity in male monkeys (Maraca arctoidcs). Food and Chem.
Toxicol. 32:565-575.
54. Mesa A. del R., Mas R., Noa M., et al. (1994): Toxicity of policosanol
in Beagle dogs: one year study. Toxicol. Lett. 73:131-90.
55. Aleman C.L., Mas R., Hernandez C., et al. (1994): A 12 months study
of policosanol oral toxicity in Sprague-Dawley rats. Toxicol. Lett. 70:77-87.
56. Aleman C.L., Noa M., Cerejido E., Mis R., Rodeiro L Hcrnindez C. and
Briffis F. (1995): Carcinogenicity of policosanol in mice: A 18 months
study. Fd. and Client. Toxicol., 33:573-578.
57. Aleman C.L., Mas R., Noa M., et al. (1994): Carcinogenicity of policosanol
in Sprague Dawley rats: A 24 months study. Teratog. Carcinog. and Mutag.,
14:239-249.
58. Rodriguez M.D. and Garcia H. (1994): Teratogenic and reproductive
studies of policosanol in the rat and rabbit. Teratog., Carcinog. and
Mutag., 14:107-113.
59. Rodriguez M.D., Garcia H. (1998): Evaluation of peri- and post-natal
toxicity of Policosanol in rats. Teratog Carcinog Mutagen 18(1):1-7.
60. Rodriguez M.D., Sanchez M., Garcia H. (1997): Multigeneration reproduction
study of policosanol in rats. Toxicol. Lett. 90:97-106. 61. Carbajal D,
Arruzazabala M. L., Mas R., et al. (1998): Interaction policosanol-warfarin
on bleeding time and thrombosis in rats. Pharmacol Res 38(2):89-91.
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