How to avoid a heart attack imagePolicosanol clinical trials header image                  A survivor unlocks the mystery of lowering cholesterol with policosanol

 

Cholest-Check Research

Policosanol Research (Partial list)

  • American Heart Journal,
    2002 Feb;143(2):356-65- "At doses of 10 to 20 mg per day, Policosanol lowers total cholesterol by 17% to 21% and low-density lipoprotein (LDL
    ) cholesterol by 21% to 29% and raises high-density lipoprotein cholesterol by 8% to 15%"

  • Policosanol more effective than statin drugs. New Hope Natural Media, 6/6/02 - "In a six-month study, 10 mg per day of Policosanol reduced total cholesterol by 16% and LDL cholesterol by 24%, and increased than Lovastatin (Mevacor®), pravastatin (Pravachol®), and Simvastatin (Zocor®), with fewer reported side effects. While some prescription drugs used to lower cholesterol may cause liver and muscle problems in rare instances, people taking Policosanol have not suffered any serious side effects"

  • Study links statins to nerve damage. Doctor's Guide, 5/13/02 - "Compared to a "control" group of people who did not have neuropathy people who had taken statins were 4 to 14 times more likely to develop polyneuropathy that did not have a known cause.

  • Nutrition Science News, 11/01 -"Policosanol is similar in function and potency to some statin drugs ... After using 10 mg/day Policosanol for two years, study participants tripled their treadmill walking distance. The placebo group experienced insignificant change"

  • Policosanol lowers cholesterol and slows lipid oxidation.
    Life Enhancement Magazine, 10/01

  • Older Adult Study. In still another new study published in the Journal of Gerontology and Biological Science-Medical Science, the effects of policosanol in older patients with high cholesterol and more than one other atherosclerotic risk factor was investigated. After six weeks on a lipid-lowering diet, patients randomly received a placebo or policosanol.

  • Policosanol (5 and 10 mg/day) significantly reduced LDL-cholesterol (16.9% and 24.4%, respectively) and total cholesterol (12.8% and 16.2%, respectively), while significantly increasing HDL-cholesterol by 14.6% and 29.1%, respectively. Triglyceride levels remained un-changed. Policosanol, but not the placebo, significantly improved cardiovascular capacity, which was assessed using the Specific Activity Scale. No serious adverse experiences occurred in the policosanol patients. The conclusions of this study were that policosanol is effective, safe and well tolerated in older patients with high cholesterol.

  • Policosanol and Leg Cramps. Angiology 2001 Feb;52(2):115-125 - "After 6 months of therapy, Policosanol significantly increased (p < 0.01) the initial claudication distance from 125.9 +/- 8.7 m to 201.1 +/- 24.8 m and the absolute claudication distance from 219.5 +/- 14.1 m to 380.7 +/- 50.2 m. These effects did not wear off but improved after long-term therapy,

"My cholesterol was 397 and my doctor wanted to put me on Lipitor but I was afraid of the side effects. Gene gave me the research information on policosanol for my doctor to review and although he was somewhat skeptical he gave me the go ahead to give it a try.

When I got my first follow up test after 8 weeks total cholesterol had dropped to 240. But the best news is that my HDL cholesterol was up which improved my ratio from 7 to 4.3 which is very good.

I am elated and my doctor was pleased and I think a little bit surprised. He said "Keep on doing what you're doing." Edith Mc Gregor

"At doses of 10 to 20 mg per day, Policosanol lowers total cholesterol by 17% to 21% and low-density lipoprotein (LDL) cholesterol by 21% to 29% and raises high-density lipoprotein cholesterol by 8% to 15%"
American Heart Journal

Dr. Michael Murray, author of Encyclopedia of Natural Medicine says this about policosanol:

"The results from the clinical studies involving nearly 30,000 total patients clearly demonstrate that policosanol is overall the absolute best answer to high cholesterol levels, whether we are talking about a nutritional supplement, herbal product or drug."

Niacin does more than lower cholesterol!
The cholesterol lowering activity of niacin was first described in the 1950s. It is now known that it does much more than lower total cholesterol.

  • Specifically, this heart supplement has been shown to lower LDL cholesterol, Lp(a) lipoprotein, triglyceride, and fibrinogen levels while simultaneously raising HDL cholesterol levels.

  • Despite the fact that niacin has demonstrated better overall results in reducing risk factors for coronary heart disease compared with other cholesterol-lowering agents,

  • physicians are often reluctant to prescribe niacin because of the bothersome flushing of the skin, a kind of like a prickly, heat rash that typically occurs 20-30 minutes after the dosage is taken. It disappears in about the same time frame.

  • To reduce flushing - Inositol hexaniacinate
    Inositol hexaniacinate is a form of niacin that has long been used in Europe to lower cholesterol levels. It is much better tolerated, in terms of both flushing and, more importantly, long-term side-effects.

  • In addition, since inositol hexaniacinate is a widely available "generic" agent, no pharmaceutical company stands to generate the huge profits that the other lipid-lowering agents have enjoyed.

  • As a result, it does not benefit from the intensive advertising that focuses upon the "statin" drugs.

  • Niacin vs. Mevacor Study
    Several studies have compared niacin to standard lipid-lowering drugs including the statin drugs. These studies have shown significant advantages for niacin.

  • For example, in one 26 week study patients were randomly assigned to receive treatment with either lovastatin (Mevacor) or niacin.1

  • The results are shown below: Lovastatin vs. Niacin in a 26-Week Study These results indicate that while lovastatin produced a greater LDL cholesterol reduction, niacin provided better overall results despite the fact that fewer patients were able to tolerate a full dosage of niacin because of skin flushing.

  • HDLs increased  33%
    The percentage increase in HDL cholesterol, a more significant indicator for coronary heart disease, was dramatically in favor of niacin (33% vs. 7%).

  • Lp(a) lipoprotein levels dropped 35%
    While niacin produced a 35% reduction in Lp(a) lipoprotein levels, lovastatin did not produce any effect. Other studies have shown that niacin can lower Lp(a) levels by an average of 38%.2,3

  • Niacin vs. Lipitor study
    Dr. Michael T. Murray has reported a recent comparative study involved niacin vs. atorvastatin (Lipitor) in which niacin should significantly better results with various cholesterol particles.4

  • Niacin and C-reactive protein (CRP)
    Statin drugs are gaining popularity as a prescription method to lower CRP, a marker of inflammation and a risk factor for heart disease. It appears that the while majority of physicians appear to be aware of the effect of Lipitor and Pravachol on C-reactive protein they do not seem to be aware that niacin (1500 mg at night) lowered it by 20%, much more meaningful reductions than those seen with Pravachol and Lipitor.5,6

  • It Works Well With Diabetics
    Because taking niacin at higher dosages (e.g., 3,000 mg or more) can impair glucose tolerance, many physicians have avoided niacin therapy in diabetics, but newer studies with slightly lower dosages (1,000 to 2000 mg) of niacin have not shown it to adversely effect blood sugar regulation.7

  • Diabetic cholesterol profiles
    If you take a look at the most common blood lipid abnormality in type 2 diabetic patients it is elevated triglyceride levels, decreased HDL cholesterol levels, and a preponderance of smaller, denser LDL particles. Niacin has been shown to address all of these areas much more significantly than the statin or other lipid lowering drugs.

  • Other occasional side-effects of niacin in higher doses include gastric irritation, nausea, and liver damage. To reduce the side effect of skin flushing you can use some of the newer time-released formulas including the prescription version Niaspan or take it just before going to bed. 

Niacin in daily doses of 250-500 mg commonly increases HDL cholesterol by 15-20%. Higher doses should be taken only under medical supervision.

 

Has your “get up and go got up and went”?
You'll be interested in this research on CQ10.

You might say this study included a little monkey business. The subjects were thirteen male and eight female baboons. These primates were fed a variety of diets that were supplemented with different amounts of vitamin E and coenzyme Q10 (CoQ10)

The purpose of the research was to measure the effectiveness of CoQ10 and vitamin E in reducing inflammation in the body. The inflammation was measured by conducting a simple blood test of C-reactive protein (CRP).          

When CRP levels were analyzed, vitamin E was found to lower levels of inflammation to an average of less than half of pre-supplementation levels. When coenzyme Q10 was added to vitamin E, CRP levels revealed a whopping seventy percent reduction in inflammation.        

In the discussion of their findings, the researchers called the results “remarkable.” They concluded that “co-supplementation with vitamin E and coenzyme Q10 significantly enhanced both anti-inflammatory and antioxidant protection.”       

Why is this so important? Inflammation and oxidation are two of the most important risks leading to a heart attack or stroke. The latest research indicates that they are far more dangerous risks than high cholesterol.

A high level of CRP in your blood indicates an increased risk for what your cardiologist describes as “destabilized atherosclerotic plaque.” These are big words for a big problem.

Interpreted in laymen’s language, when arterial plaque becomes destabilized, it can burst open and block the flow of blood through a coronary artery, resulting in an acute heart attack. And a heart attack isn’t as much fun as you might think.

One of the New England Journal of Medicine studies showed that people with high levels of C-reactive protein were almost three times as likely to die from a heart attack.

"CoQ10, is energy on call," says, Dr. Stephen Sinatra, a board certified cardiologist at the New England Heart and Longevity Center. “I have long considered CoQ10 a wonder nutrient because of its ability to support heart health.”        

In addition to energizing your heart, CoQ10 has also been shown to support the immune system, blood pressure and healthy cholesterol levels.

More than 100 clinical studies at major universities and hospitals have documented the actions of Coenzyme Q10 and now new studies have researchers heaping more praise on this nutrient.

Women with breast cancer and non-cancerous breast lesions commonly have low blood levels of CoQ10. Although there need to be more studies, Danish researcher Knud Lockwood, M.D. has had good results using high doses of CoQ10 to prevent the recurrence of breast cancer in women.                      

Chronic inflammation is also an underlying cause of many age-related diseases. A fact that until recently has been given very little attention by the medical establishment.  

If you are taking any of the statin family of drugs such as Lipitor, Zocor or Crestor to lower your cholesterol you should not be without CoQ10. These drugs can literally “kill” synthesis of CoQ10.


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